Genetic correction of induced pluripotent stem cells mediated by transcription activator-like effector nucleases targeting ALPL recovers enzyme activity and calcification in vitro

softbones October 28, 2020

0 Comments

To read more please click on the link below.
Read Article

Categories: Scientific Publications

Tags: alkaline phosphatase, Gene therapy, Genome editing, Inborn error, Metabolic Bone Disease

IonomyIonomycin Ameliorates Hypophosphatasia via Rescuing Alkaline Phosphatase Deficiency-Mediated L-type Ca2+ Channel Internalization in Mesenchymal Stem Cells

To read more please click on the link below. Read Article

Denise Goodbar November 5, 2020

0 Comments

Patient of the Month- Sharon M.

My Journey with my Soft Bones: The only hint my parents had that something was wrong with me was my teeth. My baby teeth had…

emma_richter January 3, 2023

0 Comments

Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells

To read more please click on the link below. Read Article

Denise Goodbar December 21, 2020

0 Comments

Large-scale in Vitro Functional Testing and Novel Variant Scoring via Protein Modeling Provide Insights Into Alkaline Phosphatase Activity in Hypophosphatasia

To read more please click on the link below. Read Article

softbones October 28, 2020

0 Comments

Patient of the Month- Emily H.

If you would like to make a donation to Soft Bones in honor of Emily, please click the button below! Donate Here Hi, this is…

Margaret Robb April 1, 2024

0 Comments

Responses

You must be logged in to post a comment.

Mail Address
The US Hypophosphatasia Foundation
141 Hawkins Place, #267
Boonton, NJ 07005, USA.

Organization

Programs

Community

Office Address
1719 NJ-10, Suite 315
Parsippany, NJ 07054

Follow Us on Social Media!

Disclaimer: This Website is owned by Soft Bones, Inc. All materials contained in this Website (the “Materials”) are either owned by or licensed to us and are protected by intellectual property and other laws. We retain all proprietary rights to the Materials. This Website is copyrighted. All rights are reserved. Except as expressly authorized by us, any use, copy, reproduction, display, performance, modification or retransmission of the Materials is strictly prohibited.

Related Articles

Responses